Tuesday 17 May 2016

Hyperfractionation

More (and smaller) dose/fraction than 1.8-2 Gy [1]. «Fractional doses smaller than conventional, given 2 or 3 times daily to achieve an increase in the total dose given in the same overall time as conventional [2].»
Bibliographic references:
[1] Fowler, J. (2006). Part I: Basic Concepts in Treatment Planning, 1. Practical Time-Dose Evaluations, or How to Stop Worrying and Learn to Love Linear Quadratics. In: S. Levitt, J. Purdy, C. Perez and S. Vijayakumar, ed., Technical Basis of Radiation Therapy, Practical Clinical Applications, 4th ed. Springer-Verlag Berlin Heidelberg, pp.3-31.
[2] Thames HD Jr, Peters LJ, Withers HR, Fletcher GH. Accelerated fractionation vs hyperfractionation: rationales for several treatments per day. Int J Radiat Oncol Biol Phys. 1983 Feb;9(2):127-38. Available at: https://doi.org/10.1016/0360-3016(83)90089-5.

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